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      B7-DC/CD273 (C-Fc)

      B7-DC/CD273 (C-Fc)

      型    号: abs04042
      报    价:
      分享到:

      爱必信特色产品线(全部现货):
      二抗、标签抗体、对照抗体;WB相关:ECL发光液、预染marker、预制胶;IHC相关:二抗试剂盒、组化笔;IP/CoIP试剂盒;细胞因子、信号通路调节剂;血清、BSA、蛋白酶K、CTB、TTX、CEE;凋亡试剂盒、呼吸爆发试剂盒;动植物提取物...

      abs04042B7-DC/CD273 (C-Fc)的详细资料:

      概述
      描述Recombinant Mouse Programmed Cell Death 1 Ligand 2 is produced by our Mammalian expression system and the target gene encoding Leu20-Arg219 is expressed with a Fc tag at the C-terminus.
      别名Programmed cell death 1 ligand 2,Pdcd1lg2,PD-1 ligand 2,PD-L2, PDCD1 ligand 2, B7-DC, CD273,
      形态Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
      来源Human Cells
      氨基酸序列LFTVTAPKEVYTVDVGSSVSLECDFDRRECEGIRASLQKVENDTSLQSERATLLEEQLPLGK ALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYP LAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRME PKVPRVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDV SHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAP IEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSKLTVDKSRWGNVFSCSVMHEALHNHYTQKSLSLSPGK
      内毒素水平Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
      Accession #Q9WUL5
      性能
      背景Programmed cell death 1 ligand 2 (PD-L2), also known as butyrophilin B7-DC or PDCD1 ligand 2, belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide, a 201 aa extracellular region , a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart, placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.
      溶解方法Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
      保存方法Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
      纯度Greater than 95% as determined by reducing SDS-PAGE.

      上一个 : abs04021CD32b/FCGR2 (C-6His)    下一个 :  abs04041PD-1/CD279 (C-6His)

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