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            特色生化试剂
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            CHIR99021 (CT99021) HCl (2mg)

            CHIR99021 (CT99021) HCl (2mg)

            型    号: abs818358a
            报    价:
            分享到:

            主要产品线:生化试剂(60万种)、抗体(10万种)、细胞因子、二抗、ECL发光液、蛋白marker、激动剂、抑制剂、凋亡试剂盒、BSA、动植物提取剂、蛋白酶K....

            abs818358aCHIR99021 (CT99021) HCl (2mg)的详细资料:

            概述
            描述

             CHIR-99021 monohydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.

            性能
            保存方法 -20°C
            纯度 ≥98%
            分子量 501.8
            化学式

            C??H??Cl?N?

            分子结构式
            溶解性 DMSO:93 mg/mL (185.33 mM) Ethanol:2 mg/mL (3.98 mM)
            CAS号 1797989-42-4
            外观 powder
            参考文献
            [1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

            [2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5).

            [3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3)

            [4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.

            [5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.

            上一个 : abs04205Recombinant Mouse VEGF-D(10ug)    下一个 :  abs47029858aSB216763 (5mg)

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